Related Experiment Video
Updated: May 11, 2026

Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice
Published on: February 18, 2016
[In search of the true dosage: statistics applied to the analysis of the cocaine]
L Dujourdy1, C Charvoz, M Dalmasso
1Service central des laboratoires, Institut national de police scientifique, 31, avenue Franklin-Roosevelt, 69134 Ecully cedex, France. laurence.dujourdy@interieur.gouv.fr
Abstract:
A method of separation by gas chromatography with a flame ionization detector was developed for quantifying cocaine in powders seized by the police. The method was validated by studying parameters of calibration, trueness, precision based on trueness error (or systematic bias) and random error. Total error, which is the combination of these errors, is used to confirm the method adequacy with the objectives fixed by the analyst. Accuracy profile is an efficient decision tool to do it. Results obtained with weighted regression model allow concluding that the method fits quantitation of heroin and cocaine in powders on 2 to 100% concentration (w/w) domain with 10% limits of acceptation and a risk of 5%.
Related Concept Videos
Drug Concentrations: Measurements
Plasma —...
Dosage Regimens: Designs and Approaches
Pharmacokinetic–Pharmacodynamic Relationship: Dose to Pharmacological Effect
Dose Size and Dosing Frequency: Determination Methods
Dosage Regimens: Partial Pharmacokinetic Parameters
Drug Concentration Versus Time Correlation
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the lowest drug...

