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[Adaptative immunity and pathophysiology of multiple sclerosis]
M Salou1, A Elong Ngono, A Garcia
1INSERM UMR1064, 30 boulevard J.-Monnet, Nantes cedex, France.
La Revue De Medecine Interne
|April 30, 2013
Summary
Multiple sclerosis (MS) is an inflammatory CNS disease. This review details how adaptive immune cells, including T and B lymphocytes, contribute to MS development, exploring key hypotheses.
Area of Science:
- Neuroimmunology
- Central Nervous System (CNS) Diseases
Context:
- Multiple sclerosis (MS) is characterized by inflammatory demyelination in the CNS.
- Pathology involves inflammatory infiltrates, primarily macrophages and T lymphocytes.
Purpose:
- To review evidence linking adaptive immune system cell populations to MS development.
- To detail the roles of effector and regulatory T and B lymphocytes in MS.
Summary:
- Evidence from human and animal studies (anatomopathological, genetic, immunological) implicates adaptive immunity in MS.
- Focuses on CD4(+) and CD8(+) T lymphocytes, B lymphocytes, and regulatory T and B cells.
- Presents major hypotheses explaining MS pathogenesis.
Impact:
- Provides a comprehensive overview of immune cell involvement in MS.
- Highlights the complexity of MS etiology.
- Informs future research directions in neuroimmunology and MS therapeutics.
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