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Collagen-only biomatrix as dural substitute: What happened after a 5-year observational follow-up study
Felice Esposito1, Gianluca Grimod, Luigi M Cavallo
1Department of Neurosciences and Reproductive and Odontostomatological Sciences, Division of Neurosurgery, Università degli Studi di Napoli Federico II, Naples, Italy. felice.esposito@unina.it
Objectives:
To assess long-term efficacy of the collagen-only biomatrix as a dural substitute in a large case series.
Patients And Methods:
We reviewed a prospectively acquired database of patients who underwent neurosurgical surgeries in whom the dural substitute was used and who were the subject of two previous studied with shorter follow-ups.
Results:
The present study was conducted on 111 subjects of the original 209 patients. No late complications, nor local or systemic toxicity were observed during the observational period. As a matter of facts, 5 patients (4.5%) underwent reoperation for different reasons and 2 out of 5 experienced subcutaneous fluid collections; another case (0.9%), already reported in our previous studies, developed a CSF leak after an endoscopic endonasal operation for an intra-suprasellar arachnoid cyst.
Conclusions:
Our data further confirm that the collagen-only biomatrix derived from horse equine tendon is a safe and effective dural substitute for routine neurosurgical procedures.
