Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Types of Genetic Transfer Between Organisms02:18

Types of Genetic Transfer Between Organisms

Genetic transfer occurs when genetic information is passed from one organism to another. It occurs via two mechanisms: vertical gene transfer and horizontal gene transfer. Vertical gene transfer occurs when genetic information is transferred from one generation to the next, which happens much more frequently than horizontal gene transfer. Both sexual and asexual reproduction are forms of vertical gene transfer, where one or more organisms pass some or all of their genome onto their progeny.
Homologous Recombination02:31

Homologous Recombination

The basic reaction of homologous recombination (HR) involves two chromatids that contain DNA sequences sharing a significant stretch of identity. One of these sequences uses a strand from another as a template to synthesize DNA in an enzyme-catalyzed reaction. The final product is a novel amalgamation of the two substrates. To ensure an accurate recombination of sequences, HR is restricted to the S and G2 phases of the cell cycle. At these stages, the DNA has been replicated already and the...
Gene Conversion02:08

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply to letter to the editor: Response to "A study of the perception of verbal expressions of the strength of evidence".

Science & justice : journal of the Forensic Science Society·2018
Same author

Prevention of Mammary Abscess.

Transactions. Edinburgh Obstetrical Society·2018
Same author

Demonstration of the Light Treatment of Lupus, by the Lamp Made by Messrs Marshall & Woods.

Transactions. Medico-Chirurgical Society of Edinburgh·2018
Same author

Forensic bitemark identification: weak foundations, exaggerated claims.

Journal of law and the biosciences·2017
Same author

Understanding forensic expert evaluative evidence: A study of the perception of verbal expressions of the strength of evidence.

Science & justice : journal of the Forensic Science Society·2017
Same author

A comment on the PCAST report: Skip the "match"/"non-match" stage.

Forensic science international·2016
Same journal

KLINK: A program for kinship testing with pairwise linked STR markers.

Forensic science international. Genetics·2026
Same journal

Data-driven methods allow prediction of utility of DNA rework.

Forensic science international. Genetics·2026
Same journal

Quantitative DNA/RNA fragmentation assays for estimating the time since deposition (TsD) of bloodstains.

Forensic science international. Genetics·2026
Same journal

Ensaya: An ensemble age model for prediction of chronological age in adolescents and young adults.

Forensic science international. Genetics·2026
Same journal

Comparison of key diagnostics for probabilistic interpretation of STR mixture data generated with length-based and MPS methodologies.

Forensic science international. Genetics·2026
Same journal

Likelihood Ratios Given Activity-Level Propositions for DNA Transfer Evidence: Theoretical Foundations of the HaloGen Framework (Part I).

Forensic science international. Genetics·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

DNA transfer: review and implications for casework.

Georgina Meakin1, Allan Jamieson

  • 1The Forensic Institute, 166 Buchanan Street, Glasgow, G1 2LW, UK.

Forensic Science International. Genetics
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

Understanding trace DNA transfer is crucial for forensic casework. This review examines how DNA quantity and profile quality can indicate direct or indirect transfer, acknowledging variability in results due to numerous influencing factors.

More Related Videos

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Related Experiment Videos

Last Updated: May 11, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
13:47

Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models

Published on: March 29, 2019

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

Area of Science:

  • Forensic Science
  • Molecular Biology
  • Genetics

Background:

  • Cellular material containing DNA can be transferred to surfaces through direct or indirect mechanisms.
  • Direct transfer involves physical contact or proximity (e.g., speaking, coughing), while indirect transfer occurs via an intermediary surface.
  • Trace DNA, defined as DNA not from identifiable body fluids, is critical in forensic investigations.

Purpose of the Study:

  • To evaluate whether the quantity and quality of DNA profiles can infer the mechanism of DNA transfer (direct vs. indirect).
  • To analyze experimental data on trace DNA transfer to determine its implications for forensic casework.
  • To consider the impact of various factors affecting trace DNA detection and interpretation.

Main Methods:

  • Review and analysis of existing experimental data on trace DNA transfer.
  • Examination of factors influencing DNA detection and profile generation.
  • Case study considerations including DNA transfer to skin, under fingernails, and contamination.

Main Results:

  • Trace DNA experiments yield varied results, even from similar samples.
  • Numerous factors significantly influence the detection and quality of DNA profiles.
  • The quantity and quality of recovered DNA may not consistently indicate the transfer mechanism.

Conclusions:

  • Interpreting trace DNA evidence requires careful consideration of numerous variables.
  • The variability in DNA recovery highlights the complexity of transfer mechanisms in forensic contexts.
  • Further research is needed to refine the understanding and application of trace DNA analysis in casework.