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Nuclear receptors in inflammation control: repression by GR and beyond

Yurii Chinenov1, Rebecca Gupte, Inez Rogatsky

  • 1Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, United States.

Molecular and Cellular Endocrinology
|April 30, 2013
PubMed

Insights

Nuclear receptors, like the glucocorticoid receptor (GR), play a crucial role in regulating inflammation. These transcription factors can repress inflammatory genes, offering therapeutic potential for chronic inflammatory diseases.

Area of Science:

  • Molecular Biology
  • Immunology
  • Endocrinology

Background:

  • Inflammation is a critical biological response to injury and infection.
  • Dysregulated inflammatory pathways contribute to chronic diseases like autoimmune and neurodegenerative disorders.
  • Nuclear receptors (NRs) are key transcription factors with known anti-inflammatory properties.

Purpose of the Study:

  • To explore the established and emerging roles of Nuclear Receptors (NRs) in inflammation.
  • To elucidate the mechanisms by which NRs, particularly the glucocorticoid receptor (GR), regulate inflammatory gene expression.

Main Methods:

  • Review of established and emerging literature on Nuclear Receptors and inflammation.
  • Focus on the molecular mechanisms of GR in repressing pro-inflammatory gene transcription.

Main Results:

  • NRs, including GR, are potent regulators of inflammatory signaling pathways.
  • GR directly represses the expression of genes encoding pro-inflammatory mediators like cytokines and chemokines.
  • NRs modulate transcription factor activity, cofactors, and chromatin remodeling to control inflammation.

Conclusions:

  • Nuclear receptors, especially GR, represent significant targets for managing chronic inflammatory conditions.
  • Understanding NR-mediated repression of inflammatory genes is vital for developing novel anti-inflammatory therapies.
Keywords:
Glucocorticoid receptorInflammationNuclear receptorsTranscriptional repression

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