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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Binge drinking impairs vascular function in young adults.

Melissa Goslawski¹, Mariann R Piano², Jing-Tan Bian¹

¹Department of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois.

Journal of the American College of Cardiology

|April 30, 2013

Summary

This summary is machine-generated.

Young binge drinkers exhibit impaired macrovascular and microvascular function, indicating early cardiovascular risk. This highlights the need for screening young adults with repeated binge drinking behaviors.

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Area of Science:

Cardiovascular Physiology
Vascular Biology
Young Adult Health

Background:

Binge drinking is prevalent among young adults (18-25 years).
Macrovascular and microvascular endothelial function in young binge drinkers remains understudied.
Repeated binge drinking is defined as ≥5 standard drinks (men) or ≥4 (women) in 2 hours.

Purpose of the Study:

To evaluate macrovascular and microvascular function in young binge drinkers (BD) compared to abstainers (A).
To assess cardiovascular disease risk factors in young BD versus A.

Main Methods:

Assessed cardiovascular profiles, flow-mediated dilation (FMD), and nitroglycerin (NTG)-mediated dilation in brachial arteries.
Evaluated vasoreactivity of resistance arteries from gluteal fat biopsies.
Compared measurements between BD (n=19) and A (n=17) groups aged 18-25 years.

Main Results:

BD group showed significantly lower FMD (8.4% vs 11%) and NTG-mediated dilation (19.6% vs 28.6%) compared to A.
Resistance artery endothelin-1-induced constriction was significantly enhanced in BD (p=0.032).
No significant differences were observed in blood pressure, lipoproteins, or C-reactive protein between groups.

Conclusions:

Impaired macrocirculation and microcirculation in young BD suggest early cardiovascular risk.
These vascular alterations may be preclinical signs of cardiovascular disease.
Findings support screening young adults for repeated binge drinking history.