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Updated: May 11, 2026

A BW Reporter System for Studying Receptor-Ligand Interactions
Published on: January 7, 2019
The role of C-type lectin receptors in immune homeostasis
Huimin Yan1, Naohito Ohno, Noriko M Tsuji
1Biomedial Research Institute, National Institute for Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 305-8566, Japan.
Abstract:
C-type lectin receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. Upon ligand binding, CLRs induce a variety of cellular responses, such as respiratory burst, production of cytokines and chemokines, and consequently shaping the adaptive immune responses. Recent frontier studies have demonstrated that CLRs play a significant role in development of anti-inflammatory immune responses and maintenance of host immune-homeostasis. In this review we describe the major CLRs involved in production of IL-10 by immune-related cells and functional maturation of regulatory T cells. In addition, we discuss the potential role of CLRs signaling in regulating intestinal immune-homeostasis and inflammation. Further understanding of the precise role for these receptors on immunoregulatory cells will provide unexpected opportunities for developing new therapies for inflammatory diseases.
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