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Biological study of alcohol dependence syndrome with reference to ethnic difference: report of a WHO Collaborative
I Yamashita1, T Ohmori, T Koyama
1Hokkaido University School of Medicine, Sapporo, Japan.
The Japanese Journal of Psychiatry and Neurology
|March 1, 1990
Abstract:
Inherited deficiency of acetaldehyde dehydrogenase type I (ALDH-I) was found in 43% (50/117) of normals, 33% (27/82) of schizophrenics, but only 4% (5/113) of alcoholics among Japanese. The ALDH-I deficiency was never found, however, in 146 mostly schizophrenic subjects from Europe (Basel, Moscow, Zagreb), Australia (Nedlands), India (Lucknow), Morocco (Casablanca) and Mexico (Mexico City). It was demonstrated that ALDH-I deficiency produces the flushing syndrome which inhibits the development of drinking habit and alcohol dependence syndrome.