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Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

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Related Experiment Video

Updated: May 11, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model
09:44

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Changes in the PCOS phenotype with age.

Ming-I Hsu1

  • 1Department of Obstetrics and Gynecology, Wan Fang Hospital, Taipei Medical University, No.111, Sec. 3, Xinglong Road, Taipei 11696, Taiwan. hsumingi@yahoo.com.tw

Steroids
|April 30, 2013
PubMed
Summary

Polycystic ovary syndrome (PCOS) diagnosis and complications vary with age. Managing weight in younger women with PCOS may prevent future insulin resistance and metabolic issues.

Area of Science:

  • Reproductive Endocrinology
  • Women's Health
  • Metabolic Disorders

Background:

  • Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in reproductive-aged women.
  • PCOS diagnosis relies on hyperandrogenism, oligo-amenorrhea, and polycystic ovaries.
  • Comorbidities include insulin resistance, type 2 diabetes, hypertension, and cardiovascular disease.

Purpose of the Study:

  • To examine the age-dependent nature of PCOS diagnostic criteria and complications.
  • To understand how aging affects PCOS presentation and associated risks.
  • To explore the impact of age-related changes on PCOS incidence and comorbidities.

Main Methods:

  • Review of diagnostic criteria for PCOS across different age groups.
  • Analysis of age-related changes in androgen production, ovarian morphology, and metabolic parameters.

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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

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Last Updated: May 11, 2026

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Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

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  • Comparison of PCOS manifestations in adolescent versus older women.

    • Main Results:

    • Diagnostic challenges exist in adolescents due to overlapping pubertal characteristics.
    • Hyperandrogenism and anovulation are primary in younger PCOS patients.
    • Obesity, insulin resistance, and metabolic disturbances are more prominent in older PCOS patients.

    Conclusions:

    • Age-dependent changes influence PCOS diagnosis and complications.
    • Weight management in younger PCOS patients may mitigate later-life metabolic risks.
    • Understanding age-related shifts is crucial for effective PCOS management.