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Updated: May 11, 2026

RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
Associations between human herpesvirus-6, human papillomavirus and cervical cancer
E Susan Amirian1, Karen Adler-Storthz, Michael E Scheurer
1Dan L Duncan Cancer Center and Department of Pediatrics, Baylor College of Medicine, 1 Baylor Plaza MSBCM305, Houston, TX 77030, USA.
Abstract:
Cervical cancer (CxCa) is the second most common cancer among women globally. Human papillomavirus (HPV) infection is thought to be a necessary, but not sufficient, causal factor in CxCa development. Why some women are able to clear HPV infection with no adverse effects, whereas others develop cancer, remains unclear. HHV-6 has demonstrated transformative abilities and has been shown to be present in the genital tract. However, based on the current evidence, we cannot conclude that HHV-6 is a co-factor in HPV-associated carcinogenesis. Nonetheless, future research is warranted because of several crucial gaps in the literature.
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