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Related Experiment Video

Updated: May 11, 2026

Skeletal Muscle Gender Dimorphism from Proteomics

Skeletal Muscle Gender Dimorphism from Proteomics

Published on: December 14, 2011

Expression and modification proteomics during skeletal muscle ageing.

Martin A Baraibar¹, Marine Gueugneau, Stephanie Duguez

¹Laboratoire de Biologie Cellulaire du Vieillissement, UR4, UPMC Paris 6 University, 4 place Jussieu, 75252, Paris Cedex 05, France.

|April 30, 2013

Summary

This summary is machine-generated.

Skeletal muscle ageing, or sarcopenia, involves muscle mass and strength loss. Proteomics offers insights into ageing mechanisms by analyzing protein changes and oxidative damage during this process.

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Last Updated: May 11, 2026

Skeletal Muscle Gender Dimorphism from Proteomics

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Published on: December 14, 2011

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Published on: May 18, 2017

Area of Science:

Biochemistry
Gerontology
Molecular Biology

Background:

Skeletal muscle ageing leads to sarcopenia, characterized by muscle mass and strength decline.
Proteomics, the study of proteins, presents unique challenges due to proteome complexity and variability.
Understanding molecular pathways in ageing requires advanced proteomic analysis.

Purpose of the Study:

To describe proteomic approaches for analyzing protein abundance in skeletal muscle.
To identify specific protein targets affected by oxidative stress during muscle ageing.

Main Methods:

Proteomic analysis of protein abundance.
Assessment of post-translational modifications.
Identification of protein oxidation targets.

Main Results:

Proteomic studies reveal key molecular pathways in ageing.
Analysis of protein abundance and modifications provides insights into sarcopenia.
Specific protein targets of oxidative damage in ageing muscle identified.

Conclusions:

Proteomics is crucial for unraveling the molecular basis of skeletal muscle ageing.
Proteomic approaches can identify biomarkers and therapeutic targets for sarcopenia.
Understanding protein changes and oxidative damage is key to combating muscle ageing.