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Related Experiment Video

Updated: May 11, 2026

A Minimally Invasive Model of Aortic Stenosis in Swine
06:51

A Minimally Invasive Model of Aortic Stenosis in Swine

Published on: October 20, 2023

External aortic root support: a histological and mechanical study in sheep.

Peter Verbrugghe1, Erik Verbeken, John Pepper

  • 1Centre of Experimental Cardiac Surgery, KUL, Leuven, Belgium.

Interactive Cardiovascular and Thoracic Surgery
|April 30, 2013
PubMed
Summary

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Polyethylene terephthalate mesh used for aortic root support in Marfan syndrome integrates with sheep carotid arteries. This aortic support mesh significantly enhances arterial strength without causing inflammation or necrosis, suggesting potential for long-term clinical success.

Area of Science:

  • Biomaterials Science
  • Cardiovascular Surgery
  • Histology

Background:

  • Personalized external aortic root support (PEARS) is evaluated for Marfan syndrome patients as an alternative to root replacement.
  • Long-term efficacy of PEARS in preventing aortic dissection requires further investigation.

Purpose of the Study:

  • To assess the biological incorporation of polyethylene terephthalate mesh used in PEARS.
  • To evaluate the mechanical strength of the mesh/artery composite.

Main Methods:

  • Sheep carotid arteries were encased in polyethylene terephthalate mesh for 4-6 months.
  • Exised artery segments were subjected to stress testing and histological examination.

Main Results:

  • The mesh integrated into the periadventitial tissue, forming a fibrotic layer.
Keywords:
Blood vessel prosthesisExperimentalThoracic aortic aneurysm

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Last Updated: May 11, 2026

A Minimally Invasive Model of Aortic Stenosis in Swine
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Published on: October 20, 2023

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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  • Vessel wall architecture was preserved; mild medial thinning and edema were observed in some areas.
  • Supported arterial segments showed significantly increased stiffness and tensile strength.

    • Conclusions:

    • Polyethylene terephthalate mesh incorporates into the carotid artery adventitia in sheep.
    • The composite demonstrated enhanced tensile strength with no significant adverse histological findings.
    • This supports the potential of PEARS for aortic root support in Marfan syndrome.