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Related Experiment Video

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Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
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Cortico-subthalamic connection predicts individual differences in value-driven choice bias.

Martijn J Mulder1, Wouter Boekel, Roger Ratcliff

  • 1Cognitive Science Center Amsterdam, University of Amsterdam, Nieuwe Achtergracht 129, 1018, TV, Amsterdam, The Netherlands, m.j.mulder@uva.nl.

Brain Structure & Function
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

The subthalamic nucleus (STN) connects to the ventromedial prefrontal cortex (vmPFC), influencing value-based decisions. Stronger connections predict bias towards more valuable choices in perceptual tasks.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Decision Science

Background:

  • The subthalamic nucleus (STN) and ventromedial prefrontal cortex (vmPFC) are implicated in value-based decision-making.
  • A structural connection between the STN and vmPFC may mediate value-based actions in perceptual decision tasks.

Purpose of the Study:

  • Quantify the structural connection between the STN and vmPFC.
  • Investigate if the tract-strength of this connection predicts individual differences in choice bias during perceptual decision-making.

Main Methods:

  • Probabilistic tractography was used to measure structural connectivity (tract-strength) between the STN and vmPFC.
  • Bias in perceptual decision-making was quantified using an accumulation-to-bound model, analyzing shifts in the starting point of evidence accumulation.

Main Results:

  • A significant structural connection was confirmed between the STN and vmPFC.
  • The strength of the STN-vmPFC connection predicted individual differences in choice bias towards more valuable options.
  • This connection strength did not predict bias towards more likely options.

Conclusions:

  • The cortico-subthalamic circuit, specifically the STN-vmPFC pathway, plays a role in value-based actions during perceptual decision-making.
  • This pathway is crucial for integrating value information into choice behavior.