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Related Experiment Video

Updated: May 11, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl₄) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Catechins in dietary supplements and hepatotoxicity.

Victor J Navarro¹, Herbert L Bonkovsky, Sun-Il Hwang

¹Division of Hepatology, Einstein Medical Center, 5401 Old York Road, Suite 505, Philadelphia, PA 19141, USA. NavarroV@einstein.edu

Digestive Diseases and Sciences

|April 30, 2013

Summary

Many herbal supplements contain hidden catechins linked to liver injury. This study found catechins in nearly 40% of supplements not listing them, though a direct link to liver damage wasn't proven.

Related Experiment Videos

Last Updated: May 11, 2026

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl₄) Exposure Through an Orogastric Tube

Published on: April 28, 2020

Area of Science:

Phytochemistry
Hepatology
Toxicology

Background:

Herbal dietary supplements (HDS) frequently contain green tea extract (GTE) and catechins.
The presence of GTE and catechins may not be disclosed on product labels.

Purpose of the Study:

To investigate the presence of catechins in HDS implicated in hepatotoxicity.
To determine if these undeclared catechins are associated with liver injury.

Main Methods:

Assayed 97 HDS implicated in human hepatotoxicity for the presence of catechins.
Analyzed association between catechin presence/dose and liver injury characteristics.

Main Results:

Catechins were detected in 39.7% of HDS that did not list GTE or catechins on their labels.
No statistically significant association was found between catechin presence/dose and liver injury causality, severity, or pattern.
Products marketed for weight loss showed a tendency for higher catechin levels, but concentrations were generally low.

Conclusions:

Undeclared catechins are common in HDS associated with hepatotoxicity.
While this study did not establish a direct link between GTE/catechins and hepatotoxicity, it highlights the complexity of attributing drug-induced liver injury (DILI) to HDS.