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Related Experiment Video

Updated: May 11, 2026

Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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Published on: January 20, 2022

Galectin-3: a possible complementary marker to the PSA blood test.

Vitaly Balan1, Yi Wang, Pratima Nangia-Makker

  • 1Department of Oncology and 2 Biostatistics Core Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

Oncotarget
|April 30, 2013
PubMed
Summary

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Galectin-3 shows promise as a complementary marker to prostate-specific antigen (PSA) testing for prostate cancer (PCa). Elevated galectin-3 levels in blood may aid in diagnosing metastatic PCa and monitoring recurrence.

Area of Science:

  • Oncology
  • Biochemistry
  • Urology

Background:

  • Prostate-specific antigen (PSA) is a key blood marker for prostate cancer (PCa) but faces limitations due to false positives and negatives.
  • Galectin-3, a tumor-associated protein found in seminal fluid, is processed by PSA, suggesting a potential link to PCa.

Purpose of the Study:

  • To investigate the association between galectin-3 levels (in serum and prostate tissue) and prostate cancer.
  • To evaluate galectin-3 as a potential complementary diagnostic and prognostic marker alongside PSA for PCa.

Main Methods:

  • Compared serum galectin-3 levels in non-cancer urology patients versus metastatic PCa patients.
  • Validated findings using prostate cancer tissue arrays.

Main Results:

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A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
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Last Updated: May 11, 2026

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Published on: January 20, 2022

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples
13:21

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
11:13

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  • Serum galectin-3 levels were significantly higher in patients with metastatic PCa compared to non-cancer controls.
  • Galectin-3 levels in prostate tissue and sera showed an association with PCa.

Conclusions:

  • Galectin-3 serum levels may serve as a valuable adjunct to PSA testing for initial PCa diagnosis.
  • Galectin-3 could be a useful biomarker for monitoring PCa recurrence and metastasis.