Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Venous pressure and bone formation.

P J Kelly1, J T Bronk

  • 1Section of Orthopedic Research, Mayo Clinic, Rochester, Minnesota 55905.

Microvascular Research
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inhibition of endochondral ossification during fracture repair in experimental hypothyroid rats.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2000
Same author

A dual-luciferase reporter system for studying recoding signals.

RNA (New York, N.Y.)·1998
Same author

Isolation and characterisation of immunoglobulin g and IgG subclasses of the African elephant (Loxodonta africana).

Comparative immunology, microbiology and infectious diseases·1998
Same author

Development and health care needs of lesbians.

Journal of women's health·1998
Same author

The effect of the reduction of colloid oncotic pressure, with and without reduction of osmolality, on post-traumatic cerebral edema.

Anesthesiology·1998
Same author

Middle cerebral artery main stem thrombosis in two siblings with familial thrombotic thrombocytopenic purpura.

Neurology·1998

Increased venous pressure in dogs leads to more periosteal new bone formation. This occurs because higher pressure increases fluid flow into bone tissue, signaling bone cells to grow.

Area of Science:

  • Orthopedics
  • Bone Biology
  • Vascular Physiology

Background:

  • Periosteal new bone formation is crucial for skeletal development and repair.
  • The role of venous pressure in regulating bone formation is not fully understood.
  • Understanding fluid dynamics in bone is key to comprehending bone remodeling.

Purpose of the Study:

  • To investigate the relationship between elevated venous pressure and periosteal new bone formation.
  • To explore the underlying mechanisms linking venous pressure to bone growth.
  • To determine if increased fluid passage in bone matrix influences bone formation.

Main Methods:

  • Utilized steady-state tracer techniques to measure fluid spaces within bone.
  • Measured venous pressure in canine subjects.

Related Experiment Videos

  • Quantified periosteal new bone formation rates using histomorphometry.

    • Main Results:

    • Increased venous pressure correlated with a decrease in vascular space within the bone.
    • Elevated venous pressure led to an increase in extracellular fluid space (sucrose space).
    • A significant increase in periosteal new bone formation was observed on the side with increased venous pressure.

    Conclusions:

    • The study supports the hypothesis that increased venous pressure enhances fluid passage from capillaries into the bone matrix.
    • Increased extravascular perfusion is identified as a potential factor driving enhanced periosteal bone formation.
    • Fluid flux may generate streaming potentials, acting as a signal for increased bone formation by bone cells.