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Related Experiment Video

Updated: May 11, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Psychosocial problems associated with depression at 18 months poststroke.

A De Ryck¹, E Fransen, R Brouns

¹Department of Nursing and Midwifery Sciences, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium; Department of Neurology, Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim and Hoge Beuken, Antwerp, Belgium.

International Journal of Geriatric Psychiatry

|April 30, 2013

Summary

Poststroke depression (PSD) affects 28% of stroke survivors, with reduced activity and relationship problems being key risk factors. Addressing these issues is crucial for improving patient outcomes and quality of life after stroke.

Keywords:

depression poststroke depression psychosocial problems stroke

Related Experiment Videos

Last Updated: May 11, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

Neurology
Psychiatry
Epidemiology

Background:

Poststroke depression (PSD) is a common complication following a stroke, with reported prevalence rates ranging from 20% to 65%.
Understanding the incidence and identifying risk factors for PSD is crucial for timely intervention and improved patient outcomes.

Purpose of the Study:

To determine the incidence of poststroke depression (PSD) at 18 months after stroke.
To identify the key risk factors associated with the development of PSD at 18 months poststroke.

Main Methods:

A prospective, longitudinal epidemiological study was conducted, following 125 stroke patients for 18 months.
Poststroke depression (PSD) was assessed using the Cornell Scale for Depression (CSD) and Montgomery and Åsberg Depression Rating Scale.
Activities of daily living and social engagement were measured using the Stroke Impact Scale (SIS), and relational problems were assessed via questionnaire.

Main Results:

The incidence of depression (CSD score ≥8) was 28% at 18 months poststroke.
Patients with PSD exhibited greater dependency in activities of daily living, and more significant physical and cognitive impairments.
Increased patient activity (per unit on SIS) was associated with a 5% decreased risk of depression (OR=0.95, 95% CI=0.93-0.97).
Persistent relational problems since stroke onset increased the risk of depression by approximately four and a half times (OR=4.48, 95% CI=1.17-16.87).

Conclusions:

Reduced activity levels and relationship problems stemming from stroke are significant predictors of developing PSD at 18 months.
Further research into psychosocial risk factors for PSD is essential due to its detrimental impact on stroke rehabilitation and overall quality of life.