Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Incremental health care resource utilization, costs, and predictors of high costs in generalized myasthenia gravis.

Journal of managed care & specialty pharmacy·2026
Same author

Economic Evaluation of Thymectomy for the Treatment of Nonthymomatous Myasthenia Gravis.

JAMA network open·2026
Same author

Burden of glucocorticoid use in commercially insured adults with generalized myasthenia gravis in the United States: A retrospective claims-based analysis.

Medicine·2026
Same author

ENGAGE: Analyzing the value of virtual reality in a patient-centric immersive learning program in myasthenia gravis for healthcare professionals.

Frontiers in neurology·2026
Same author

Urinary dysfunction in myasthenia Gravis: a cross-sectional case-control study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Appropriate use of steroids for patients with generalized Myasthenia Gravis: an international Delphi study.

Therapeutic advances in neurological disorders·2025
Same journal

Targeted Muscle Reinnervation for Intuitive Prosthetic Control.

Muscle & nerve·2026
Same journal

Urinary Dysfunction in Myasthenic Syndromes: A Scoping Review of Clinical Features and Treatment-Related Associations.

Muscle & nerve·2026
Same journal

Join AANEM.

Muscle & nerve·2026
Same journal

Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

Muscle & nerve·2026
Same journal

AANEM News & Insights.

Muscle & nerve·2026
Same journal

Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

Muscle & nerve·2026
See all related articles

Related Experiment Video

Updated: May 11, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
15:43

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes

Published on: January 7, 2013

Asymptomatic/pauci-symptomatic creatine kinase elevations (hyperckemia).

Nicholas J Silvestri1, Gil I Wolfe

  • 1Department of Neurology, University at Buffalo, Buffalo General Medical Center, 100 High Street, Buffalo, New York 14203-1126, USA. njs6@buffalo.edu

Muscle & Nerve
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

Asymptomatic elevations in creatine kinase (CK) require careful evaluation. This review offers a rational approach for neuromuscular clinicians to identify underlying causes of hyperCKemia.

Related Experiment Videos

Last Updated: May 11, 2026

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes
15:43

Assessment of Mitochondrial Functions and Cell Viability in Renal Cells Overexpressing Protein Kinase C Isozymes

Published on: January 7, 2013

Area of Science:

  • Biochemistry
  • Neurology
  • Clinical Diagnostics

Background:

  • Elevated creatine kinase (CK) levels are common clinical findings.
  • Asymptomatic hyperCKemia presents diagnostic challenges and controversies.
  • CK is vital for cellular energy metabolism.

Purpose of the Study:

  • To review literature on asymptomatic hyperCKemia.
  • To provide a rational clinical approach for evaluation.
  • To identify potential underlying causes of elevated CK.

Main Methods:

  • Literature review of patient series with asymptomatic hyperCKemia.
  • Synthesis of diagnostic strategies.
  • Analysis of identifiable underlying causes.

Main Results:

  • Asymptomatic hyperCKemia necessitates a structured diagnostic pathway.
  • Various identifiable causes contribute to elevated CK levels.
  • A systematic approach improves diagnostic yield.

Conclusions:

  • A rational clinical approach is essential for managing asymptomatic hyperCKemia.
  • Identifying underlying causes of elevated CK is crucial for patient management.
  • Further research can refine diagnostic criteria and evaluation strategies.