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Piper nigrum and piperine: an update.
Murlidhar Meghwal1, T K Goswami
1Agricultural and Food Engineering Department, Indian Institute of Technology, Kharagpur, WB, India.
Phytotherapy Research : PTR
|April 30, 2013
Summary
Black pepper contains piperine, a compound with significant medicinal properties. This review explores piperine
Area of Science:
- Pharmacology and Phytochemistry
- Nutritional Science
- Medicinal Chemistry
Background:
- Black pepper (Piper nigrum L.) is a globally utilized spice, primarily recognized for its pungent compound, piperine.
- Beyond culinary applications, black pepper possesses notable medicinal and preservative qualities.
- Emerging research highlights piperine's impact on p-glycoprotein and enzyme systems, influencing biotransformation processes.
Purpose of the Study:
- To comprehensively review the chemical constituents of black pepper and piperine.
- To elucidate the diverse biological activities and medicinal properties of piperine.
- To examine the effects of processing on black pepper and piperine and discuss their future therapeutic potential.
Main Methods:
- Literature review of modern cell, animal, and human studies.
- Analysis of chemical constituents and biological activities.
- Evaluation of processing effects and future applications.
Main Results:
- Piperine demonstrates fundamental effects on p-glycoprotein and various enzyme systems.
- Identified biotransformative effects include chemoprevention, detoxification, and enhanced drug bioavailability.
- Piperine exhibits immunomodulatory, antioxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties.
Conclusions:
- Black pepper, through its active compound piperine, offers a wide spectrum of medicinal benefits.
- Piperine's influence on drug metabolism and its inherent therapeutic properties warrant further investigation.
- The review underscores the significant potential of black pepper and piperine in both traditional and modern medicine.
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