Spectrophotometric estimation of azithromycin in tablets

Area of Science:

• Analytical Chemistry
• Pharmaceutical Analysis
• Spectrophotometry

Background:

• Accurate quantification of azithromycin in pharmaceutical formulations is crucial for ensuring therapeutic efficacy and patient safety.
• Existing analytical methods may present limitations in terms of cost, sensitivity, or complexity.
• Development of simple and economical analytical techniques is essential for routine quality control in pharmaceutical industries.

Purpose of the Study:

• To develop and validate a simple, sensitive, accurate, and economical visible spectrophotometric method for the estimation of azithromycin.
• To assess the applicability of the developed method for azithromycin determination in tablet formulations.
• To evaluate the method's performance regarding interference and agreement with labeled quantities.

Main Methods:

• Visible spectrophotometry utilizing the reduction of potassium permanganate in an alkaline medium by azithromycin.
• Measurement of the decrease in absorbance of potassium permanganate at 547 nm.
• Quantification of azithromycin within the concentration range of 2-20 μg/ml.

Main Results:

• The developed method demonstrated good linearity, sensitivity, accuracy, and precision for azithromycin estimation.
• No significant interference was observed from common excipients found in azithromycin tablets.
• The results obtained from tablet analysis showed good agreement with the labeled drug content.

Conclusions:

• The proposed visible spectrophotometric method is suitable for the accurate and economical determination of azithromycin in tablet formulations.
• This method offers a reliable alternative for routine quality control analysis of azithromycin.
• The simplicity and sensitivity of the method make it advantageous for pharmaceutical analysis.