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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Histology of the Gastrointestinal (GI) Tract

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Related Experiment Videos

Primary gastrointestinal lymphoma.

Amir Aledavood1, Mohammad Reza Ghavam Nasiri, Bahram Memar

  • 1Cancer Research Center, Omid Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences
|April 30, 2013
PubMed
Summary

This study reviews primary gastrointestinal (GI) lymphoma cases, finding stomach and small intestine are common sites. Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype, with a 5-year survival rate of 53%.

Keywords:
Diffuse Large B-Cell LymphomaExtranodal LymphomaPrimary Gastrointestinal Lymphoma

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Area of Science:

  • Oncology
  • Gastroenterology
  • Hematology

Background:

  • Extranodal lymphoma commonly affects the gastrointestinal (GI) tract, often presenting as non-Hodgkin's lymphoma.
  • Primary GI lymphoma involves lymphoma originating within the GI tract without evidence of nodal disease.
  • Understanding the clinicopathological features and treatment outcomes of primary GI lymphoma is crucial for patient management.

Purpose of the Study:

  • To analyze the clinicopathological characteristics of primary GI lymphoma.
  • To evaluate the treatment results and survival rates of patients with primary GI lymphoma.
  • To identify common sites and histological subtypes of primary GI lymphoma.

Main Methods:

  • Retrospective review of 30 primary GI lymphoma cases treated at Omid Hospital (Mashhad, Iran) between 2006 and 2011.
  • Collection and analysis of clinical, paraclinical, and radiological data from patient medical records.
  • Histopathological confirmation of non-Hodgkin's lymphoma and subtype classification.

Main Results:

  • The most frequent primary sites were the stomach (46.7%) and small intestine (26.7%).
  • Diffuse large B-cell lymphoma (DLBCL) was the predominant subtype (53.3%).
  • The overall 5-year survival rate was 53%, with a median survival of 60 months. Chemotherapy (CHOP regimen) was administered to 93.3% of patients.

Conclusions:

  • Primary GI lymphoma predominantly affects the stomach and small intestine.
  • Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma are the most common histologic subtypes.
  • Effective treatment strategies, including chemotherapy, contribute to patient survival.