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Related Concept Videos

Lateralization01:28

Lateralization

Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Cerebral Hemispheres01:05

Cerebral Hemispheres

The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...

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Related Experiment Video

Updated: May 11, 2026

Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
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Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability

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Hemispheric differences in ischemic stroke: is left-hemisphere stroke more common?

Vishnumurthy Shushrutha Hedna1, Aakash N Bodhit, Saeed Ansari

  • 1Department of Neurology, University of Florida, Gainesville, FL, USA.

Journal of Clinical Neurology (Seoul, Korea)
|April 30, 2013
PubMed
Summary
This summary is machine-generated.

Left-hemisphere ischemic strokes are more common and associated with worse outcomes than right-hemisphere strokes. Large-vessel ischemic strokes, often due to atherosclerosis or cardioembolism, are more frequent in the left middle cerebral artery territory.

Keywords:
acute strokecollateralsendovascular interventionendovascular treatmentischemic strokemechanical thrombectomymortality after strokemotor gradeoutcome after stroke

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Stroke Medicine

Background:

  • Understanding stroke mechanisms is crucial for developing effective therapies.
  • Investigating hemispheric differences in ischemic stroke can reveal key mechanistic insights.
  • Cerebral artery anatomy and blood flow dynamics may influence stroke laterality.

Purpose of the Study:

  • To determine if left- and right-hemisphere ischemic strokes differ in frequency, severity, functional outcome, and mortality.
  • To assess if large-vessel ischemia is more prevalent in the left middle cerebral artery territory due to circulatory factors.

Main Methods:

  • Analysis of a combined dataset of 317 patients with ischemic stroke, excluding specific stroke types.
  • Correlation of stroke laterality and vascular distribution with outcomes using logistic regression.
  • Identification of large-vessel stroke etiologies as atherosclerosis and cardioembolism.

Main Results:

  • Left-hemispheric strokes were more frequent (54%) and associated with higher admission NIHSS scores, increased mortality, and greater rates of mechanical thrombectomy.
  • Ischemic strokes were more common in the left middle cerebral artery distribution, driven by a higher incidence of large-vessel ischemic stroke.
  • Significant differences were observed in event frequency, mortality, stroke severity (NIHSS), and intervention rates between hemispheres.

Conclusions:

  • Left-hemispheric ischemic strokes appear more frequent and often result in worse outcomes compared to right-hemispheric strokes.
  • A higher incidence of large-vessel ischemic strokes in the left middle cerebral artery territory contributes to these observed hemispheric disparities.
  • Excluding middle cerebral artery strokes diminishes the observed hemispheric differences, suggesting its significant role.