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Novel binding partners and differentially regulated phosphorylation sites clarify Eps8 as a multi-functional adaptor

Debbie L Cunningham1, Andrew J Creese, Giulio Auciello

  • 1Cancer Research UK Growth Factor Signalling Group, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, United Kingdom.

Plos One
|April 30, 2013
PubMed
Summary

This study identifies new phosphorylation sites on Eps8 protein, revealing its regulation by fibroblast growth factor receptor (FGFR) and Src kinases. It also uncovers novel binding partners involved in cell signaling and vesicle trafficking.

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