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Related Concept Videos

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
NF-kB-dependent Signaling Pathway02:26

NF-kB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

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Related Experiment Video

Updated: May 11, 2026

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
10:57

NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells

Published on: January 12, 2020

NF-κB pathway in colitis-associated cancers.

Emilie Viennois, Fengyuan Chen, Didier Merlin

    Translational Gastrointestinal Cancer
    |April 30, 2013
    PubMed
    Summary

    Colitis-associated cancer, a subtype of colorectal cancer, involves the NF-κB signaling pathway. Inhibiting this pathway shows promise as a powerful anti-cancer strategy for these inflammatory conditions.

    Area of Science:

    • Gastroenterology and Oncology
    • Molecular Biology
    • Cancer Research

    Background:

    • Colorectal cancer (CRC) is a leading cause of cancer death globally.
    • Inflammatory bowel diseases (IBD), such as ulcerative colitis and Crohn's disease, are linked to CRC development.
    • The NF-κB signaling pathway is critically involved in colonic inflammation and cancer.

    Purpose of the Study:

    • To review the role of the NF-κB signaling pathway in colitis-associated carcinogenesis.
    • To highlight the significance of NF-κB in the development and progression of CRC in the context of IBD.

    Main Methods:

    • Literature review focusing on studies investigating NF-κB signaling in colitis-associated cancer.
    • Analysis of the molecular mechanisms linking inflammation, NF-κB, and cancer development.
    Keywords:
    Colon cancerNF-κBcolitisinflammationpharmacology

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    NF-κB-dependent Luciferase Activation and Quantification of Gene Expression in Salmonella Infected Tissue Culture Cells
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    Published on: December 4, 2018

    Main Results:

    • The NF-κB pathway plays a pivotal role in key cancer processes including apoptosis evasion, tumor promotion, and tumor maintenance.
    • Aberrant NF-κB activity is strongly associated with the development of colitis-associated cancer.

    Conclusions:

    • The NF-κB signaling pathway is a critical driver of colitis-associated carcinogenesis.
    • Targeting the NF-κB pathway represents a promising therapeutic strategy for treating colitis-associated colorectal cancer.