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Updated: May 11, 2026

Accessing the Cytotoxicity and Cell Response to Biomaterials

Accessing the Cytotoxicity and Cell Response to Biomaterials

Published on: July 8, 2021

Bone morphogenetic proteins: periodontal regeneration.

Subramaniam M Rao¹, Gauri M Ugale, Shivaraj B Warad

¹Department of Periodontics, P M Nadagowda Memorial Dental College and Hospital, Bagalkot, Karnataka, India.

North American Journal of Medical Sciences

|April 30, 2013

Summary

Bone morphogenetic proteins (BMPs) show promise for regenerating periodontal tissues lost to disease. Studies indicate BMPs effectively promote the new formation of cementum, periodontal ligament, and alveolar bone, aiding in periodontal defect repair.

Keywords:

Bone Bone morphogenetic proteins Gene therapy Osteogenic protein Periodontal regeneration

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Accessing the Cytotoxicity and Cell Response to Biomaterials

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Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Area of Science:

Periodontal medicine
Regenerative medicine
Biomaterials science

Background:

Periodontitis causes significant attachment and bone loss, necessitating tissue regeneration.
Regenerating periodontal tissues involves the de novo formation of cementum, periodontal ligament, and alveolar bone.
Therapeutic strategies for new bone formation are critical for successful periodontal regeneration.

Purpose of the Study:

To evaluate the efficacy of bone morphogenetic proteins (BMPs) in regenerating periodontal tissues.
To synthesize existing research on BMPs for periodontal defect treatment.

Main Methods:

A systematic literature search was conducted using databases like PubMed, MEDLINE, Cochrane, and Google.
Studies focusing on animal and human subjects were included.
Data on the use of BMPs for periodontal defect regeneration were analyzed.

Main Results:

All included studies demonstrated notable regeneration of periodontal tissues.
Bone morphogenetic proteins exhibited significant osteoinductive potential.
BMPs were effective in promoting the formation of new bone, cementum, and periodontal ligament.

Conclusions:

Bone morphogenetic proteins are a promising therapeutic agent for periodontal regeneration.
BMPs facilitate the repair of periodontal defects by stimulating tissue formation.
Further research into BMPs can advance periodontal regenerative therapies.