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Published on: May 12, 2023
[Research on the effect of Aconitum soongaricum and its processed products on AA rat]
Fei-Cui Zhao1, Ling Fu, Chao Wu
1Affiliated Traditional Chinese Medical Hospital, Medical University, Xinjiang 830000, China. zzffcc@126.com
Objective:
To observe the effect of Aconitum soongaricum and its processed products on adjuvant arthritis (AA) rat and its mechanism.
Methods:
Rats were radomly divided into normal group, model group, positive group, Aconitum soongaricum and its processed products (including Pharmacopoeia method, document method, Kazak method three processed products), which divided into high dose, middle dose, low dose groups (30.65, 15.32, 7.66 mg/kg); Except normal group, prepared AA rat model by using Freund's complete Adjuvant (FCA) for the rest groups; Each group was administered for 23 days after the rat model was established, observed rats ankle swelling degree and arthritis index. Determined content of interleukin-1beta (IL-1beta) and cortisol (Cort) in serum by ELISA method.
Results:
(1) The swelling degree of model group was higher than that of normal group (P < 0.01). Compared with model group, the swelling degree and AI of Aconitum soongaricum and all of its processed products groups were lower (P < 0.01 or P < 0.05). (2) The content of IL-1beta and Cort in serum of model group was higher than that of normal group (P < 0.01). Compared with model group, the content of Cort in serum of positive group, Aconitum soongaricum groups (high dose, middle dose, low dose), its Pharmacopoeia method processed product groups (high dose, middle dose) and its document method processed product groups (high dose) were lower (P < 0.01); Compared with model group, the content of IL-1beta in serum of positive group, Aconitum soongaricum groups (high dose, middle dose, low dose), its Pharmacopoeia method processed product groups (high dose, middle dose, low dose) its document method processed product group (high dose) and its Kazak method processed product group (middle dose) were lower (P < 0.01 or P < 0.05).
Conclusion:
Aconitum soongaricum and all of its processed products groups are proved with anti-inflammatory effect, which possible mechanism would be restraining inflammation cell factor such as IL-1beta and Cort in serum of AA rat.