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Published on: September 29, 2023
Antifungal agents from Pseudallescheria boydii SNB-CN73 isolated from a Nasutitermes sp. termite
Charlotte Nirma1, Véronique Eparvier, Didier Stien
1CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 1 Avenue de la Terrasse, Gif-sur-Yvette, France.
Abstract:
Defense mutualisms between social insects and microorganisms have been described in the literature. The present article describes the discovery of a Pseudallescheria boydii strain isolated from Nasutitermes sp. The microbial symbiont produces two antifungal metabolites: tyroscherin and N-methyltyroscherin, a compound not previously described in the literature. Methylation of tyroscherin has confirmed the structure of N-methyltyroscherin. Both compounds are effective antifungal agents with favorable selectivity indices for Candida albicans and Trichophyton rubrum.
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