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Updated: May 11, 2026
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
Prognostic value of HOXB7 mRNA expression in human oesophageal squamous cell cancer
Xuan Xie1, Shui-shen Zhang, Jing Wen
1State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, People's Republic of China.
Objective:
This study was to determine the role of HOXB7 in predicting outcomes of patients with oesophageal squamous cell cancer (OSCC).
Methods:
Samples were collected from 179 OSCC patients. HOXB7 mRNA expression was measured by quantitative real-time polymerase chain reaction.
Results:
HOXB7 mRNA expression was up-regulated in 85.1% of OSCC tumorous tissues, and correlated with age, pathological T and N category, as well as cancer-specific survival (CSS). However, subgroup analysis revealed its discernibility on CSS was only pronounced in early stage.
Conclusions:
HOXB7 mRNA expression might serve as a novel prognostic biomarker for resected OSCC patients in early stage.