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Updated: May 11, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Organocatalyzed asymmetric synthesis of morphans
Ben Bradshaw1, Claudio Parra, Josep Bonjoch
1Laboratori de Química Orgánica, Facultat de Farmàcia, IBUB, Universitat de Barcelona , Av. Joan XXIII, s/n, 08028, Barcelona, Spain.
Abstract:
A general effective organocatalyzed synthesis of enantioenriched morphans with up to 92% ee was developed. The morphan scaffold was constructed in a one-pot tandem asymmetric organocatalyzed Michael addition followed by a domino Robinson annulation/aza-Michael intramolecular reaction sequence from easily available starting materials.
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