Related Experiment Video
Updated: May 11, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
[Research progress of N-Myc roles in hematopoiesis and hematologic malignancies]
Li-Jing Shen1, Lan-Fang Cao, Fang-Yuan Chen
1Department of Hematology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Abstract:
N-Myc oncogene plays an important role in the process of hematopoietic cell proliferation and differentiation in embryos. Once the body suffers from hematologic malignancies, the expression of N-Myc would increase and significantly associate with disease progression. In this article the structure of N-Myc, the regulatory mechanism in the different hematopoietic lineages, the interaction in each signal pathways, the transgenic animal model of overexpression, and intervention by drugs are reviewed.
More Related Videos
Related Concept Videos
Abnormal Proliferation
Differentiation of Common Myeloid Progenitor Cells
Role of Hematopoietic Growth Factors
Thrombopoietin (TPO), mainly released by the liver,...
Hematopoiesis
Regulation of Hematopoietic Stem Cells
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

