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Related Experiment Video

Updated: May 11, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

[Prostate brachytherapy: indications and outcomes].

C Hennequin1, L Cormier, P Richaud

  • 1Service de cancérologie radiothérapie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefeaux, 75475 Paris, France. christophe.hennequin@sls.aphp.fr

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

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Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2023

Low dose-rate prostate brachytherapy offers excellent oncologic outcomes for favorable-risk prostate cancer patients. This treatment option provides similar results to surgery and external beam radiation therapy (EBRT).

Area of Science:

  • Urology
  • Radiation Oncology
  • Oncology

Context:

  • Prostate brachytherapy is a minimally invasive treatment for prostate cancer.
  • Understanding its indications and outcomes is crucial for treatment selection.
  • This study reviews data from 1995-2012.

Purpose:

  • To summarize the indications and outcomes of low dose-rate prostate brachytherapy.
  • To evaluate its efficacy and toxicity compared to other prostate cancer treatments.

Summary:

  • Low dose-rate brachytherapy is indicated for favorable-risk prostate cancer and selected intermediate-risk cases (PSA ≤ 15 ng/mL or Gleason 7 (3+4) without extracapsular extension).
  • Oncologic outcomes show a 10-year biochemical control rate approaching 90%, comparable to surgery and external beam radiation therapy (EBRT).

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  • Common side effects include temporary urinary irritative symptoms and acute urinary retention (5-15%). High prostate volume (>50 cc) or International Prostate Symptom Score (IPSS) predict toxicity.

    • Impact:

    • Prostate brachytherapy is a validated treatment option alongside active surveillance, surgery, and EBRT.
    • It offers comparable oncologic control with preserved sexual function in 60% of patients.
    • Patient selection considering prostate volume and IPSS is key to minimizing toxicity.