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Updated: May 11, 2026
09:44
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
[Acetaminophen (paracetamol) causing renal failure: report on 3 pediatric cases].
J Le Vaillant1, L Pellerin, J Brouard
1Service de pédiatrie médicale, CHU de Caen, avenue de la Côte-de-Nacre, 14033 Caen, France. justine.levaillant@yahoo.com
Summary
Acetaminophen overdose can cause acute kidney injury, even without liver damage. Prompt monitoring of renal function is crucial for managing severe acetaminophen poisoning in children.
Area of Science:
- Toxicology
- Nephrology
- Pediatrics
Background:
- Acetaminophen (APAP) overdose is a common cause of acute liver failure.
- Renal failure is a rare complication, occurring in 1-2% of APAP overdose cases.
- The exact pathophysiology of renal toxicity from APAP is not fully understood.
Observation:
- This study reports three adolescent cases of acute renal failure following voluntary acetaminophen intoxication.
- One patient experienced severe renal injury without elevated liver enzymes (hepatic transaminases).
- None of the patients required hemodialysis, but one developed metabolic complications.
Findings:
- Acute tubular necrosis is the primary renal pathology in acetaminophen toxicity.
- Renal manifestations can occur independently of liver disease.
- Early renal symptoms typically appear 2-7 days post-ingestion.
Implications:
- Renal function monitoring is essential in managing severe acetaminophen poisoning, especially in children.
- Early identification and supportive care can prevent severe renal complications.
- This case series highlights the potential for significant renal injury in acetaminophen overdose, even without concurrent liver injury.
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