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Related Concept Videos

Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

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Related Experiment Video

Updated: May 11, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

[Primary biliary cirrhosis and pregnancy].

G Ducarme1, J Bernuau2, D Luton3

  • 1Service de gynécologie obstétrique, centre hospitalier départemental, 85000 La Roche-sur-Yon, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|May 1, 2013
PubMed
Summary

Pregnancy in primary biliary cirrhosis (PBC) requires careful management. Ursodeoxycholic acid (UDCA) is key, with delivery mode depending on cirrhosis and varices severity.

Keywords:
Cirrhose biliaire primitiveGrossesseManagementPregnancyPrimary biliary cirrhosisPrise en charge

Related Experiment Videos

Last Updated: May 11, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

Area of Science:

  • Hepatology
  • Immunology
  • Gastroenterology

Context:

  • Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease affecting small bile ducts.
  • The exact etiology of PBC remains unknown, with potential immunologic and environmental factors implicated.
  • Infertility is common, yet pregnancy is possible in women with PBC, with or without cirrhosis.

Purpose:

  • To outline the management of pregnancy in women with primary biliary cirrhosis.
  • To emphasize the importance of a multidisciplinary approach involving gastroenterologists and obstetricians.
  • To detail medical treatment and delivery recommendations based on disease severity.

Summary:

  • Management involves ursodeoxycholic acid (UDCA) and close maternal/fetal monitoring.
  • Non-cirrhotic patients on UDCA typically have normal pregnancies and vaginal deliveries.
  • Cirrhotic patients require UDCA, variceal evaluation, and potentially endoscopic ligature or beta-blockers.
  • Elective cesarean section is advised for those with significant esophageal or gastric varices to mitigate bleeding risks.

Impact:

  • Provides guidance for managing a complex pregnancy scenario.
  • Highlights the role of UDCA in improving pregnancy outcomes for PBC patients.
  • Informs clinical decisions regarding delivery methods to ensure maternal safety.