Improving the reliability and reporting of genetic association studies

Area of Science:

• Genetics
• Psychiatry
• Addiction Research

Background:

• Candidate gene studies have a history of inconsistent replication.
• The journal Drug and Alcohol Dependence receives many genetic association study submissions.
• Ensuring credibility in genetic association research is crucial for the field.

Purpose of the Study:

• To outline the journal's approach to evaluating genetic association studies.
• To promote the publication of credible and balanced genetic research.
• To encourage adherence to reporting guidelines for enhanced transparency.

Main Methods:

• Discussion of the journal's editorial policies regarding genetic association studies.
• Highlighting the importance of the STrengthening the REporting of Genetic Association studies (STREGA) initiative.
• Encouraging authors to follow STREGA guidelines for submission.

Main Results:

• The journal aims to foster a positive contribution to the field of genetic association studies.
• Adherence to STREGA guidelines enhances transparency in reporting.
• Inconsistent findings in genetic association studies necessitate clear reporting standards.

Conclusions:

• Drug and Alcohol Dependence journal advocates for rigorous reporting standards in genetic association studies.
• The STREGA guidelines are recommended to improve the quality and reproducibility of submitted research.
• Transparent reporting is essential for advancing the understanding of genetic influences on addiction.