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Low endogenous thrombin potential in trained subjects.

Christina Cimenti1, Axel Schlagenhauf, Bettina Leschnik

  • 1Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Austria.

Thrombosis Research
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

Regular exercise training reduces the risk of thrombosis by lowering endogenous thrombin potential, despite acute clotting activation during exercise. This study clarifies the paradox between exercise-induced clotting activation and reduced thrombosis risk in trained individuals.

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Area of Science:

  • Cardiovascular Physiology
  • Hemostasis and Thrombosis Research
  • Exercise Science

Background:

  • Exercise paradoxically activates clotting in tests but reduces thrombosis risk in individuals.
  • Investigating exercise's impact on in vitro plasma thrombin generation is crucial for understanding hemostasis.
  • This study addresses the discrepancy between acute clotting activation and chronic thrombosis risk in exercising populations.

Purpose of the Study:

  • To evaluate the effect of exercise performance status on in vitro plasma thrombin generation.
  • To compare hemostatic function between trained athletes and sedentary individuals.
  • To elucidate the mechanisms behind the lower incidence of thrombosis in trained persons.

Main Methods:

  • Compared 56 trained subjects with 98 age-matched sedentary volunteers.
  • Analyzed thrombin generation using calibrated automated thrombography (CAT).
  • Quantified microparticles, prothrombin fragments 1+2, thrombin-antithrombin complex, tissue factor pathway inhibitor, antithrombin, and prothrombin.

Main Results:

  • Trained subjects exhibited significantly lower endogenous thrombin potential (p = 0.007) and microparticles (p = 0.001).
  • Prothrombin fragments 1+2 and thrombin-antithrombin complex were higher in trained subjects, while antithrombin and prothrombin were lower.
  • Exercise intensity (maximal and submaximal power output) negatively correlated with endogenous thrombin potential and thrombin peak.

Conclusions:

  • Trained individuals possess a lower endogenous thrombin potential compared to sedentary individuals.
  • This reduced thrombin generation capacity may explain the lower thrombosis incidence in trained subjects.
  • Exercise training influences hemostasis markers, potentially mitigating thrombosis risk despite acute exercise-induced clotting activation.