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Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
Diabetes and bone health
Marianna Antonopoulou1, Gül Bahtiyar, Mary Ann Banerji
1SUNY Downstate Medical Center, United States.
Maturitas
|May 1, 2013
Summary
Diabetes increases fracture risk. This review examines how glycemic control and diabetes medications impact bone health, exploring screening tools for at-risk diabetic populations.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Bone Biology
Background:
- Global rise in type 2 diabetes incidence.
- Diabetics face higher morbidity, mortality, and fracture rates.
- Osteoporotic fractures linked to diabetes types 1 and 2 and certain treatments.
Purpose of the Study:
- Review the impact of glycemic control on bone health.
- Evaluate effects of specific anti-diabetic medications (TZDs, SUs, DPP-4 inhibitors, GLP-1 agonists).
- Examine potential anabolic roles of insulin and metformin on bone.
Main Methods:
- Literature review of current research.
- Analysis of existing studies on diabetes and bone metabolism.
- Evaluation of screening tools for bone health in diabetics.
Main Results:
- Glycemic control significantly influences bone health in diabetics.
- Certain anti-diabetic medications may affect fracture risk.
- Insulin and metformin show potential as bone-anabolic agents.
- Current screening tools for diabetic bone health have limitations.
Conclusions:
- Understanding medication effects is crucial for managing diabetic bone health.
- Individualized treatment strategies are needed for at-risk diabetic patients.
- Further research on screening and therapeutic interventions is warranted.
Keywords:
AGEsBMDCAHDMDPP-4DXADiabetesFRAXFSHFracturesGHGIPGLPIGF-1IGFBP3LHOsteoporosisPCOSPPAR-gamma agonistsPTHSHBGTZDsThiazolidinedionesadvanced glycation endproductsbone mineral densitycongenital adrenal hyperplasiadiabetes mellitusdipeptydil petptidase-4dual-energy X-ray absorptiometryfollicle stimulating hormonefracture risk assessment toolgastric inhibitory polypeptideglucagon like peptidegrowth hormoneinsulin like growth factor 1insulin-like growth factor binding protein 3luteinizing hormoneparathyroid hormoneperoxisome proliferator-activated receptor gammapolycystic ovarian syndromesex hormone binding globulinthiazolidinediones
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