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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
What is the Skeletal System?01:02

What is the Skeletal System?

Overview
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.

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Related Experiment Video

Updated: May 11, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Diabetes and bone health.

Marianna Antonopoulou1, Gül Bahtiyar, Mary Ann Banerji

  • 1SUNY Downstate Medical Center, United States.

Maturitas
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

Diabetes increases fracture risk. This review examines how glycemic control and diabetes medications impact bone health, exploring screening tools for at-risk diabetic populations.

Keywords:
AGEsBMDCAHDMDPP-4DXADiabetesFRAXFSHFracturesGHGIPGLPIGF-1IGFBP3LHOsteoporosisPCOSPPAR-gamma agonistsPTHSHBGTZDsThiazolidinedionesadvanced glycation endproductsbone mineral densitycongenital adrenal hyperplasiadiabetes mellitusdipeptydil petptidase-4dual-energy X-ray absorptiometryfollicle stimulating hormonefracture risk assessment toolgastric inhibitory polypeptideglucagon like peptidegrowth hormoneinsulin like growth factor 1insulin-like growth factor binding protein 3luteinizing hormoneparathyroid hormoneperoxisome proliferator-activated receptor gammapolycystic ovarian syndromesex hormone binding globulinthiazolidinediones

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Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

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Last Updated: May 11, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

Area of Science:

  • Endocrinology
  • Metabolic Diseases
  • Bone Biology

Background:

  • Global rise in type 2 diabetes incidence.
  • Diabetics face higher morbidity, mortality, and fracture rates.
  • Osteoporotic fractures linked to diabetes types 1 and 2 and certain treatments.

Purpose of the Study:

  • Review the impact of glycemic control on bone health.
  • Evaluate effects of specific anti-diabetic medications (TZDs, SUs, DPP-4 inhibitors, GLP-1 agonists).
  • Examine potential anabolic roles of insulin and metformin on bone.

Main Methods:

  • Literature review of current research.
  • Analysis of existing studies on diabetes and bone metabolism.
  • Evaluation of screening tools for bone health in diabetics.

Main Results:

  • Glycemic control significantly influences bone health in diabetics.
  • Certain anti-diabetic medications may affect fracture risk.
  • Insulin and metformin show potential as bone-anabolic agents.
  • Current screening tools for diabetic bone health have limitations.

Conclusions:

  • Understanding medication effects is crucial for managing diabetic bone health.
  • Individualized treatment strategies are needed for at-risk diabetic patients.
  • Further research on screening and therapeutic interventions is warranted.