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Related Concept Videos

Borderline Personality Disorder01:25

Borderline Personality Disorder

Borderline Personality Disorder is a complex and multifaceted mental health condition characterized by pervasive instability in interpersonal relationships, self-image, emotions, and impulse control. This instability manifests in extreme emotional reactions, fear of abandonment, and self-destructive behaviors. The disorder significantly impacts daily functioning, often leading to distress in both personal and professional domains.
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Person perception is influenced by both external behaviors and the observer’s internal characteristics, including personality traits. Individuals with dark personality traits, comprising psychopathy, Machiavellianism, and narcissism — collectively known as the dark triad – exhibit manipulative and exploitative tendencies in social contexts. These traits affect how they perceive others and how they are perceived.The Role of Dark Personality Traits in Person PerceptionBlack et al. (2014) explored...
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Dissociative Identity Disorder

Dissociative Identity Disorder (DID), previously termed multiple personality disorder, is a complex psychological condition characterized by the presence of two or more distinct identities or personality states. Each identity exhibits unique patterns of behavior, voice, and mannerisms and may possess separate memories and emotional responses. The alternating control between identities can result in memory gaps and challenges in recalling daily activities, often exacerbating the individual's...
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Oppositional Defiant Disorder

A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
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Developmental differences in diffusion tensor imaging parameters in borderline personality disorder.

Antonia S New1, David M Carpenter, M Mercedes Perez-Rodriguez

  • 1The Mental Illness Research Education and Clinical Center, James J. Peters Veterans Affairs Medical Center, NY 10029, USA. antonia.new@mssm.edu

Journal of Psychiatric Research
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

Adolescent borderline personality disorder (BPD) shows reduced white matter integrity in key brain tracts. This suggests a potential early biological marker for BPD risk, differing from adult presentations.

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Published on: September 12, 2011

Area of Science:

  • Neuroimaging
  • Developmental Neuroscience
  • Psychiatry

Background:

  • Borderline personality disorder (BPD) often emerges in adolescence, yet early predictors and biological underpinnings remain poorly understood.
  • Abnormal functional brain connectivity in BPD suggests white matter alterations, but diffusion tensor imaging (DTI) studies in adults are inconclusive, and none exist for adolescents.
  • Early detection and intervention are crucial for reducing BPD severity.

Purpose of the Study:

  • To investigate white matter integrity using DTI in adolescents and adults with BPD compared to healthy controls.
  • To identify potential early biological markers for BPD.
  • To explore developmental differences in white matter abnormalities in BPD.

Main Methods:

  • Diffusion tensor imaging (DTI) tractography was performed on 38 individuals with BPD (14 adolescents, 24 adults) and 32 healthy controls (13 adolescents, 19 adults).
  • Tract-specific fractional anisotropy (FA) was analyzed to assess white matter integrity.
  • Voxelwise TBSS (Tract-Based Spatial Statistics) analysis was used for detailed examination of FA differences.

Main Results:

  • Adolescents with BPD exhibited significantly lower fractional anisotropy (FA) in the inferior longitudinal fasciculus (ILF) bilaterally compared to adolescent controls.
  • ILF FA was notably higher in adolescent controls than in BPD adolescents, BPD adults, and adult controls.
  • Further analysis revealed reduced FA in BPD adolescents within the uncinate and occipitofrontal fasciculi compared to controls.

Conclusions:

  • Adolescent BPD may involve a failure to achieve the typical developmental peak in white matter FA, unlike healthy adolescents.
  • These white matter tract abnormalities in adolescent BPD might not be apparent in adulthood, despite persistent functional connectivity issues.
  • The findings suggest a potential biological marker for identifying individuals at risk for developing BPD.