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Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Decreased gray matter volume of the medial orbitofrontal cortex in panic disorder with agoraphobia: a preliminary

Kyoung-Sae Na¹, Byung-Joo Ham, Min-Soo Lee

¹Department of Psychiatry, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Progress in Neuro-Psychopharmacology & Biological Psychiatry

|May 1, 2013

Abstract

Background:

Patients with panic disorder with agoraphobia (PDA) have clinical symptoms such as the fear of being outside or of open spaces from which escape would be difficult. Although recent neurobiological studies have suggested that fear conditioning and extinction are associated with PDA, no study has examined the possible structural abnormalities in patients with PDA.

Methods:

This preliminary study compares the gray matter volume among patients with PDA, those with panic disorder without agoraphobia (PDW), and healthy controls (HC) using high-resolution 3.0 T magnetic resonance imaging (MRI) with voxel-based morphometry (VBM).

Results:

Compared with HC, patients with PDA showed decreased gray matter volume in their left medial orbitofrontal gyrus. However, differences were not found in the gray matter volumes of patients with PDW and whole panic disorder compared with HC.

Conclusions:

These findings suggest that the phobic avoidance found in patients with PDA arise from abnormalities in the medial orbitofrontal cortex, which plays an important role in fear extinction. Future studies should investigate the neuroanatomical substrates of PDA and distinguish them from those of PDW.

Keywords:

ANOVA API ASI-R Acute Panic Inventory Agoraphobia Analysis of Variance Anxiety Severity Index, revised version DARTEL DMN DSM-IV Default Mode Network Diagnostic and Statistical Manual for Mental Disorders, Fourth edition Diffeomorphic Anatomical Registration using Exponentiated Lie Algebra FWE Family-Wise Error Gray matter HC Healthy Controls MINI MNI MP-RAGE MRI Magnetic Resonance Imaging Magnetization Prepared Rapid Acquisition Gradient Echo Mini-International Neuropsychiatric Interview Montreal Neurological Institute PD PDA PDSS PDW Panic Disorder Panic Disorder Severity Scale Panic Disorder with Agoraphobia Panic Disorder without Agoraphobia Panic disorder Prefrontal cortex ROIs Regions of Interest SPSS STAI Spielberger State-Trait Anxiety Inventory Statistical Package for the Social Sciences TIV Total Intracranial Volume VBM Voxel-Based Morphometry Voxel-based morphometry fMRI functional Magnetic Resonance Imaging (fMRI)

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