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Depression: Overview01:18

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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Long-term Depression01:05

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

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Published on: April 26, 2024

Screening for depression in a single CF centre.

Gary Latchford1, Alistair J A Duff

  • 1Leeds Institute of Health Sciences, University of Leeds, UK; Department of Clinical and Health Psychology, Leeds Teaching Hospitals NHS Trust, UK.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|May 1, 2013
PubMed
Summary
This summary is machine-generated.

Screening for depression in cystic fibrosis (CF) patients revealed significant differences between the Hospital Anxiety and Depression Scale (HADS) and Patient Health Questionnaire (PHQ-9) tools. A notable number of patients reported suicidal ideation, highlighting the need for appropriate mental health screening in CF care.

Keywords:
Cystic fibrosisDepressionScreeningSuicide

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Area of Science:

  • Medical research
  • Psychiatry
  • Epidemiology

Background:

  • Cystic Fibrosis (CF) patients experience mental distress.
  • The International Depression and Anxiety Epidemiological Study (TIDES) aims to collect prevalence data for mental distress in CF patients.
  • This UK pilot study compared screening instruments and assessed self-harm risk in CF patients.

Purpose of the Study:

  • To compare the performance of two mental health screening instruments in adults with CF.
  • To measure the risk of self-harm in this population.
  • To inform the selection of appropriate screening tools for depression in CF.

Main Methods:

  • Two validated screening instruments, the Hospital Anxiety and Depression Scale (HADS) and the Patient Health Questionnaire for depression (PHQ-9), were administered to adult CF patients.
  • Data were collected from patients attending the Regional Adult CF Unit in Leeds, UK.

Main Results:

  • A total of 232 adult CF patients participated in the study.
  • Depression prevalence varied significantly: 5.6% on HADS versus 33.4% on PHQ-9.
  • 10.4% of patients (24 individuals) endorsed the suicide risk item on the PHQ-9.

Conclusions:

  • There are major discrepancies in depression detection rates between HADS and PHQ-9 in CF patients.
  • A significant minority of CF patients reported suicidal ideation.
  • Further research is required to identify the optimal screening tool for depression in CF, incorporating self-harm assessment.