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Updated: May 11, 2026
07:05
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
Interaction between host cells and microbes in chemotherapy-induced mucositis
1School of Pharmacy and Medical Sciences, University of South Australia, Adelaide 5001, Australia. andrea.stringer@unisa.edu.au
Nutrients
|May 1, 2013
Summary
Chemotherapy can cause mucositis by altering the gut microbiota. This review explores how changes in intestinal ecology link to signaling pathways involved in mucositis development.
Area of Science:
- Oncology
- Microbiology
- Gastroenterology
Background:
- Chemotherapy frequently causes mucositis, a painful inflammation of the digestive tract lining.
- The intestinal microbiota's role in mucositis pathobiology is increasingly recognized.
- Chemotherapeutic agents significantly impact intestinal microbial composition and function.
Purpose of the Study:
- To review and identify connections between known mucositis signaling pathways and chemotherapy-induced alterations in the intestinal microbiota.
- To explore the pathological consequences of dysbiosis following chemotherapy.
Main Methods:
- Literature review of studies investigating mucositis, chemotherapy, and the intestinal microbiota.
- Analysis of signaling pathways implicated in mucositis pathogenesis.
- Correlation of identified pathways with changes in gut microbial ecology.
Main Results:
- Chemotherapy-induced dysbiosis is a significant factor in mucositis development.
- Specific microbial metabolites and host-microbe interactions influence inflammatory signaling.
- Altered intestinal ecology can exacerbate mucositis severity through various molecular pathways.
Conclusions:
- The intestinal microbiota plays a critical role in chemotherapy-induced mucositis.
- Targeting the gut microbiota or its associated signaling pathways may offer novel therapeutic strategies for mucositis prevention and treatment.
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