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Updated: May 11, 2026

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
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A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

A novel device to stretch multiple tissue samples with variable patterns: application for mRNA regulation in

Jasmin Imsirovic1, Kelsey Derricks2, Jo Ann Buczek-Thomas2

  • 1Department of Biomedical Engineering; Boston University; Boston, MA USA.

Biomatter
|May 1, 2013
PubMed
Summary

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This summary is machine-generated.

Mechanical stretch variability impacts cell function. This study introduces a novel device to apply variable strain, revealing that altered mechanical signals influence cell-matrix interaction molecules, with potential for tissue engineering.

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Tissue Engineering

Background:

  • Cells experience variable mechanical stimuli in vivo, especially in respiratory and circulatory systems.
  • The impact of variable mechanical stretch on cell function is largely unexplored.
  • Understanding these effects is crucial for tissue regeneration and disease modeling.

Purpose of the Study:

  • To investigate the effects of variable mechanical stretch on cell-matrix interactions.
  • To develop and validate a novel uniaxial stretching device capable of applying variable strain.
  • To explore the potential of tuned mechanical variability in tissue engineering.

Main Methods:

  • Designed, built, and validated a uniaxial stretching device for 3D tissue constructs.
Keywords:
extracellular matrixmechanotransductionsignalingstretch

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  • Applied variable uniaxial strain (0-75% variability) to neonatal rat lung fibroblasts on Gelfoam scaffolds.
  • Utilized RT-PCR to quantify mRNA levels of key cell-matrix interaction molecules.

    • Main Results:

    • Variable strain significantly altered the expression of molecules involved in cell-matrix interactions.
    • Specific molecules, like syndecan-4, showed a significant response to a particular level of variability (25%).
    • The study demonstrated that mechanical variability can upregulate or downregulate specific gene expressions.

    Conclusions:

    • Cycle-by-cycle variability in mechanical strain influences the expression of cell-matrix interaction molecules.
    • Mechanical variability can be a tool to selectively tune tissue construct composition.
    • Further research may identify optimal variability levels for specific tissue engineering applications.