[The cooperative effect of hydrocortisone, adrenaline and high-density lipoproteins in regulating liver hexokinase...

The authors described a cooperative effect of glucocorticoids, catecholamines and high density lipoproteins (HDLP), based on increased hexokinase and glucokinase biosynthesis in the liver, resulting in elevated activity of the respective enzymes. This effect was completely blocked by actinomycin-D (a DNA-dependent inhibitor of RNA synthesis), vinblastine (an inhibitor of the microtubular apparatus and intracellular shift) and gordox (an inhibitor of serine proteinases). The modulating effect of HDLP with relation to the adaptive hormones emphasizes the cooperative nature of the new mechanism of enzymatic synthesis induction.