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Updated: May 11, 2026

Subclavian Vein Puncture As an Alternative Method of Blood Sample Collection in Rats

Subclavian Vein Puncture As an Alternative Method of Blood Sample Collection in Rats

Published on: November 18, 2018

Should postmortem subclavian blood be considered a peripheral or central sample?

D Kimberley Molina¹, Veronica M Hargrove

¹Bexar County Medical Examiner's Office, San Antonio, TX 78229, USA. kmolina@bexar.org

The American Journal of Forensic Medicine and Pathology

|May 1, 2013

Summary

Subclavian blood drug concentrations differ from femoral and heart blood. Precisely noting the blood source in toxicology reports is crucial for accurate interpretation of postmortem drug levels.

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Area of Science:

Forensic Toxicology
Pharmacokinetics

Background:

Postmortem redistribution of drugs can affect concentration accuracy.
The classification of blood sample sources (central vs. peripheral) is critical for interpretation.

Purpose of the Study:

To determine if subclavian (SC) blood is a peripheral or central source for postmortem drug analysis.
To compare drug concentrations in femoral (F), SC, and heart (H) blood samples.

Main Methods:

Analysis of 20 different drugs in blood samples from 28 postmortem cases.
Comparison of drug concentrations across F, SC, and H blood sources.

Main Results:

SC blood drug concentrations did not consistently reflect F or H blood levels.
Benzodiazepine concentrations in SC blood closely matched H blood.
SC blood drug levels were generally higher than F blood (1.3x) and lower than H blood (0.77x).

Conclusions:

Subclavian blood should not be unilaterally classified as peripheral or central.
Accurate interpretation of postmortem drug concentrations requires specific notation of the blood sample source.