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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Current modalities of accelerated partial breast irradiation.

John A Cox¹, Todd A Swanson

¹Department of Radiation Oncology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0711, USA.

Nature Reviews. Clinical Oncology

|May 1, 2013

Summary

Accelerated partial breast irradiation (APBI) offers an alternative to whole-breast irradiation (WBI) for early-stage breast cancer, showing excellent local control and cosmetic outcomes. APBI may improve treatment accessibility by reducing time and volume.

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Area of Science:

Oncology
Radiation Oncology
Surgical Oncology

Background:

Whole-breast irradiation (WBI) is standard adjuvant therapy post-breast-conserving surgery.
Accelerated partial breast irradiation (APBI) is an emerging alternative for select early-stage breast cancer patients.
APBI offers reduced treatment volume and duration compared to WBI.

Purpose of the Study:

To review available modalities for APBI delivery.
To outline patient selection criteria and consensus guidelines for APBI.
To discuss current controversies and ongoing trials comparing APBI with WBI.

Main Methods:

Review of early trials and ongoing phase III trials comparing APBI and WBI.
Analysis of APBI delivery modalities.

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Evaluation of patient selection criteria and guideline recommendations.

Main Results:

Early APBI trials demonstrate excellent local control rates.
Good-to-excellent cosmetic outcomes are associated with APBI.
APBI potentially overcomes logistical barriers of WBI, increasing access to breast-conserving therapy.

Conclusions:

APBI is a viable alternative to WBI for selected early-stage breast cancer patients.
Ongoing research and trials are crucial for long-term outcome data and refining APBI protocols.
Further investigation into APBI patient selection and delivery modalities is warranted.