Deubiquitinases as potential anti-cancer targets for gold(III) complexes
Jing-Jing Zhang1, Kwan-Ming Ng, Chun-Nam Lok
1Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Abstract:
A panel of [Au(III)(C^N)(R2NCS2)](+) (HC^N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.
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