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Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Published on: April 23, 2021

White-matter changes correlate with cognitive functioning in Parkinson's disease.

Rebecca J Theilmann1, Jason D Reed, David D Song

  • 1Department of Radiology, University of California San Diego La Jolla, CA, USA.

Frontiers in Neurology
|May 1, 2013
PubMed
Summary

Diffusion tensor imaging reveals subtle white-matter changes in Parkinson's disease (PD) patients without dementia. These changes in brain tissue diffusivity correlate with cognitive impairments, suggesting potential early indicators of decline.

Keywords:
Parkinson’s diseasecerebral cortexcognitiondiffusion tensor imagingwhite-matter

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Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Neuroscience

Background:

  • Cortical white-matter integrity in Parkinson's disease (PD) without dementia remains unclear.
  • Previous studies show inconclusive Diffusion Tensor Imaging (DTI) findings.
  • The link between white-matter changes and cognitive function in PD is underexplored.

Purpose of the Study:

  • To characterize tissue diffusivity changes in PD patients without dementia.
  • To investigate the relationship between white-matter integrity and cognitive functioning.
  • To explore the functional significance of DTI findings in early PD.

Main Methods:

  • Diffusion Tensor Imaging (DTI) was performed on 25 PD patients and 26 controls.
  • Automated tract-based analysis quantified fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD).
  • Neuropsychological tests assessed executive functions and visuospatial abilities, correlated with DTI metrics.

Main Results:

  • PD patients showed widespread reductions in FA and increases in MD, primarily due to increased RD.
  • Increased AD was observed in specific right frontal tracts in PD patients.
  • Cognitive measures correlated with FA in specific white-matter tracts, not motor severity.

Conclusions:

  • Abnormal tissue diffusivity in white matter is present in PD patients without dementia.
  • These diffusivity changes correlate with executive functioning and visuospatial abilities.
  • DTI metrics may serve as sensitive indicators of subtle cognitive changes and potential future decline in PD.