Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes II: Tumor Suppressor Genes

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Quantitative single-cell analysis of PML-RARα oncogene-induced DNA damage along cell cycle progression.

Methods (San Diego, Calif.)·2026

Same author

Therapeutic inhibition of telomeric DNA damage response rescues hematopoietic dysfunction driven by telomere shortening and aging.

Nature aging·2026

Same author

MiTo: tracing the phenotypic evolution of somatic cell lineages via mitochondrial single-cell multi-omics.

Nature communications·2026

Same author

Mechanical load inhibits cancer growth in mouse and human hearts.

Science (New York, N.Y.)·2026

Same author

Lorlatinib in patients with <i>ALK</i>-positive metastatic NSCLC previously treated with an ALK inhibitor: results from a phase IV study.

Future oncology (London, England)·2026

Same author

Author Correction: Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.

Nature·2026

Search research articles

Related Experiment Video

Updated: May 11, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

TRIM proteins in cancer.

Valeria Cambiaghi¹, Virginia Giuliani, Sara Lombardi

¹Department of Experimental Oncology, European Institute of Oncology, IEO, Milan, Italy.

Advances in Experimental Medicine and Biology

|May 1, 2013

Summary

Tripartite motif (TRIM) proteins regulate cell growth and differentiation, impacting cancer. Some TRIM genes fuse with others, creating proteins that drive cancer initiation and progression, like PML-RARalpha in Acute Promyelocytic Leukaemia.

More Related Videos

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Related Experiment Videos

Last Updated: May 11, 2026

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Multiomics Analysis of TMEM200A as a Pan-Cancer Biomarker

Published on: September 15, 2023

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

The tripartite motif (TRIM) protein family plays crucial roles in cellular processes including growth, differentiation, and apoptosis.
Alterations in TRIM proteins can affect transcriptional regulation and cell proliferation, implicating them in carcinogenesis.
Specific TRIM gene translocations generate fusion proteins that are key drivers of cancer initiation and progression.

Purpose of the Study:

To discuss the biological functions of TRIM proteins in the context of cancer.
To highlight the role of TRIM proteins in various cancers, including those with and without chromosomal rearrangements.

Main Methods:

Review of existing literature on TRIM proteins and their involvement in cancer.
Analysis of specific TRIM gene translocations and their resulting fusion proteins.
Examination of TRIM protein functions, such as ubiquitination and tumor suppression.

Main Results:

Four TRIM family genes are frequently translocated, forming fusion proteins implicated in cancer.
The PML-RARalpha fusion protein, resulting from the t(15;17) translocation in Acute Promyelocytic Leukaemia (APL), is a well-known example.
Other TRIM proteins contribute to cancer development through mechanisms like ubiquitination or loss of tumor suppressor functions, even without chromosomal rearrangements.

Conclusions:

TRIM proteins are significant regulators of carcinogenesis due to their involvement in fundamental cellular processes.
Chromosomal translocations involving TRIM genes, such as PML, are critical in specific leukemia types.
Understanding TRIM protein functions is essential for comprehending cancer development and exploring therapeutic strategies.