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Related Experiment Video

Updated: May 11, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

[Monogenic obesity in human].

Kazumichi Onigata¹

¹Postgraduate Clinical Practice Center, Shimane University Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|May 2, 2013

Summary

This summary is machine-generated.

Genetic mutations in the leptin-melanocortin pathway cause early-onset obesity. Identifying these obesity genes aids in understanding metabolic abnormalities and hereditary obesity syndromes.

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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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Published on: June 3, 2016

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Last Updated: May 11, 2026

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography

Published on: April 4, 2012

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

Published on: June 3, 2016

Area of Science:

Genetics
Endocrinology
Metabolic Disorders

Context:

Obesity is a complex condition influenced by genetic and environmental factors.
The leptin discovery illuminated central pathways regulating appetite and body weight.
Monogenic obesity in humans is a recognized genetic disorder.

Purpose:

To explore the genetic underpinnings of obesity, particularly focusing on the leptin-melanocortin axis.
To identify specific gene mutations associated with monogenic and hereditary obesity.
To understand the molecular basis of early-onset obesity and associated metabolic issues.

Summary:

Mutations in genes such as Leptin, leptin receptor, proopiomelanocortin (POMC), prohormone convertase 1 (PC1), and melanocortin receptor-4 (MC4-R) are linked to monogenic obesity.
These genetic defects lead to early-onset obesity and distinct metabolic abnormalities.
Gene mutations are also implicated in hereditary syndromes presenting with symptomatic obesity.

Impact:

Advances understanding of the genetic architecture of obesity.
Provides targets for diagnosing and potentially treating genetic forms of obesity.
Highlights the critical role of the leptin-melanocortin pathway in weight regulation.