Biodegradable core-shell carriers for simultaneous encapsulation of synergistic actives

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery Systems

Background:

• Simultaneous encapsulation of multiple synergistic drugs is crucial for effective combination therapy.
• Existing carrier systems struggle with efficient encapsulation and controlled release of drugs in precise ratios.

Purpose of the Study:

• To develop a novel biodegradable core-shell carrier system for efficient co-delivery of hydrophilic and hydrophobic drugs.
• To demonstrate the controlled release and therapeutic efficacy of synergistic anticancer drugs encapsulated in the novel carrier.

Main Methods:

• Fabrication of a biodegradable core-shell carrier using a one-step, solvent-free microfluidic process.
• Encapsulation of hydrophilic doxorubicin hydrochloride in the aqueous core and hydrophobic paclitaxel in the solid shell.
• Characterization of particle size, composition, and drug loading efficiency; assessment of in vitro drug release and efficacy in cancer cell lines.

Main Results:

• Achieved high encapsulation efficiency for both hydrophilic and hydrophobic drugs within the core-shell structure.
• Demonstrated precise control over particle size and composition.
• Showcased simultaneous controlled release of synergistic anticancer drugs, leading to significant efficacy in cancer-derived cell lines.
• Developed a stable, storable powder formulation of drug-loaded particles.

Conclusions:

• The novel biodegradable core-shell carrier system offers an efficient and precise platform for co-delivering synergistic drug combinations.
• The solvent-free microfluidic fabrication method provides a scalable and versatile approach for advanced drug delivery applications.
• This technology holds significant potential for improving combination cancer therapies and encapsulating other active ingredients.